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KADIS Das Karlsburger Diabetes-Management System KADIS® - weltweit einzigartiges Computerprogramm zur schnellen und sicheren Prüfung von individuellen Therapie- optionen - wurde am Institut für Diabetes »Gerhardt Katsch« Karlsburg entwickelt.

www.kadis-online.de
 

DCC Diabetes ServiCe Center Karlsburg (DCC®), das ortsunabhängig und rund um die Uhr telemedizinische Dienstleistungen zur Verfügung stellt, wurde von Institut für Diabetes »Gerhardt Katsch« Karlsburg gegründet.

www.diabetes-service-center.de
 

Publications

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2012 nach oben

The First Aptamer-Apheresis Column Specifically for Clearing Blood of β1-Receptor Autoantibodies
- A Successful Proof of Principle Using Autoantibody-Positive SHR Rats -

Gerd Wallukat, PhD; Annekathrin Haberland, PhD; Sabine Berg; Angela Schulz, PhD; Ernst-Joachim Freyse, MD; Claudia Dahmen; Andreas Kage, MD; Michael Dandel, MD; Roland Vetter, MD; Eckhard Salzsieder, PhD; Reinhold Kreutz, MD; Ingolf Schimke, PhD
Circulation Journal, Official Journal of the Japanese Circulation Society, 2012, CJ-12-0212, Advance Publication by-J-STAGE

2011 nach oben

Model-based Decision support in Diabetes Care.
Salzsieder E., Vogt L., Kohnert K.-D., Heinke P., Augstein P.
Computer Methods and Programs in Biomedicine - 102(2011)206-218

The Use of a Computer Program to Calculate the Mean Amplitude of Glycemic Excursions
Fritzsche G., Kohnert K.-D., Heinke P., Vogt L., Salzsieder E.
Diabetes Technology & Therapeutics - 13(2011)3, 319-325

CGM in Combination with Personalized Decision Support (PDS) - a new Tool to Improve Routine Diabetes Care
Salzsieder E., Vogt L., Augstein P.
Proceedings IFMBE Budapest 2011

2010 nach oben

Model-based Decision support in Diabetes Care.
Salzsieder E, Vogt L, Kohnert KD, Heinke P, Augstein P. Comput Methods Programs Biomed.
2010 Jul 9. [Epub ahead of print]

Enhanced GIP and attenuated GLP-1 incretin effects during IVGTT in Wistar rats under DPP-4 inhibition
E.-J- Freyse et al.
2010

Acceptance and outcome of knowledge-based decision support in routine diabetes care is strongly related to HbA1c at baseline
P. Augstein et al.
2010

2009 nach oben

Morphology of pancreatic islets: a time course of pre-diabetes in Zucker fatty rats.
Augstein P, Salzsieder E.
Methods Mol Biol. 2009;560:159-89.

Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents.
Kohnert KD, Augstein P, Zander E, Heinke P, Peterson K, Freyse EJ, Hovorka R, Salzsieder E.
Diabetes Care. 2009 Jun;32(6):1058-62. Epub 2009 Feb 24.

Relationships between glucose variability and conventional measures of glycemic control in continuously monitored patients with type 2 diabetes.
Kohnert KD, Vogt L, Augstein P, Heinke P, Zander E, Peterson K, Freyse EJ, Salzsieder E.
Horm Metab Res. 2009 Feb;41(2):137-41. Epub 2009 Feb 12.

Impact of cytokine- and FasL-induced apoptosis in the beta-cell line NIT-1.
Augstein P, Heinke P, Schober C, Salzsieder E.
Horm Metab Res. 2009 Mar;41(3):207-12. Epub 2008 Oct 29.

The Karlsburg Diabetes Management System: from discovery to application.
P. Augstein, L. Vogt, K.-D. Kohnert, P. Heinke, V. Heuzeroth, E. Salzsieder, Res. Adv. In
Diabetes Care (2009), 1, 1-20.

Morphology of pancreatic islets: a time course of pre-diabetes in Zucker Fatty Rats.
P. Augstein, E. Salzsieder, In: methods in Molecular Biology 560, Type 2 Diabetes, Methods and Protocols, C- Stocker eds.,
Human Press 2009, 159-190.

Therapieoptionen für die persönliche Stoffwechselführung von Diabetikern schnell und sicher prüfen - das KADIS®- Konzept im Diabetes-Gesundheits-Netzwerk
Vogt L, Augstein P, Kohnert KD, Puchert A, Heinke P, Fritzsche G, Heuzeroth V, Salzsieder E.
In e-Health 2010, F. Duesberg (Hrsg.) 166-172

2008 nach oben

Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (Deltapsim) in the pancreatic beta-cell line NIT-1.
Augstein P, Heinke P, Salzsieder E, Grimm R, Giebel J, Salzsieder C, Harrison LC.
Diab Vasc Dis Res. 2008 Sep;5(3):198-204.

Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance.
Augstein P, Berg S, Heinke P, Altmann S, Salzsieder E, Demuth HU, Freyse EJ.
Diabetes Obes Metab. 2008 Sep;10(10):850-61. Epub 2007 Oct 29.

Cytokine- and FasL-induced ß-cell death in type 1 diabetes.
P. Augstein, E. Salzsieder, P. Heinke, H.-C. Schober, L.C. Harrison. Current Trends in
Endocinology (2008); 3, 31-55.

Realität in der integrierten Versorgung, eine Zwischenbilanz.
H. Korb, E. Salzsieder, F. Gries,
In: Realität der Integrierten Versorgung 2008, Taunus BKK, 30-35.

2007 nach oben

Telemedicine-based KADIS combined with CGMS has high potential for improving outpatient diabetes care.
Salzsieder E, Augstein P, Vogt L, Kohnert KD, Heinke P, Freyse EJ, Azim Ahmed A, Metwali Z, Salman I, Attef O. J
Diabetes Sci Technol. 2007 Jul;1(4):511-21.

Outpatient assessment of Karlsburg Diabetes Management System-based decision support.
Augstein P, Vogt L, Kohnert KD, Freyse EJ, Heinke P, Salzsieder E.
Diabetes Care. 2007 Jul;30(7):1704-8. Epub 2007 Apr 27.

Chronic hyperglycemia but not glucose variability determines HbA1c levels in well-controlled patients with type 2 diabetes.
Kohnert KD, Augstein P, Heinke P, Zander E, Peterson K, Freyse EJ, Salzsieder E.
Diabetes Res Clin Pract. 2007 Sep;77(3):420-6. Epub 2007 Feb 28.

Integratives Diabetes-Betreuungsnetzwerk (IDN).
E. Salzsieder, P. Augstein, L. Vogt,
Landestechnologie Anzeiger (2007), 1, 16.

2005 nach oben

Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone.
Wargent E, Stocker C, Augstein P, Heinke P, Meyer A, Hoffmann T, Subramanian A, Sennitt
MV, Demuth HU, Arch JR, Cawthorne MA. Diabetes Obes Metab. 2005 Mar;7(2):170-81.

2004 nach oben

Cytokines activate caspase-3 in insulinoma cells of diabetes-prone NOD mice directly and via upregulation of Fas.
Augstein P, Bahr J, Wachlin G, Heinke P, Berg S, Salzsieder E, Harrison LC. J
Autoimmun. 2004 Dec;23(4):301-9.

Fas ligand down-regulates cytokine-induced Fas receptor expression on insulinoma (NIT-1), but not islet cells, from autoimmune nonobese diabetic mice.
Augstein P, Heinke P, Salzsieder E, Berg S, Rettig R, Salzsieder C, Harrison LC.
Endocrinology. 2004 Jun;145(6):2747-52. Epub 2004 Mar 19.

2003 nach oben

IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction.
Wachlin G, Augstein P, Schröder D, Kuttler B, Klöting I, Heinke P, Schmidt S.
J Autoimmun. 2003 Jun;20(4):303-12.

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide.
Martinez NR, Augstein P, Moustakas AK, Papadopoulos GK, Gregori S, Adorini L, Jackson DC,
Harrison LC. J Clin Invest. 2003 May;111(9):1365-71.

Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells.
Augstein P, Dunger A, Heinke P, Wachlin G, Berg S, Hehmke B, Salzsieder E. Biochem Biophys
Res Commun. 2003 May 2;304(2):378-84.

Surface and intracellular Fas expression associated with cytokine-induced apoptosis in rodent islet and insulinoma cells.
Augstein P, Wachlin G, Berg S, Bahr J, Salzsieder C, Hehmke B, Heinke P, Salzsieder E.
J Mol Endocrinol. 2003 Apr;30(2):163-71.

2002 nach oben

Cell Surface Trafficking of Fas in NIT-1 Cells and Dissection of Surface and Total Fas Expression.
Augstein P, Dunger A, Salzsieder C, Heinke P, Kubernath R, Bahr J, Fischer U, Rettig R & Salzsieder E,
2002 Biochem.Biophys.Res.Commun. 290 443-451.

2001 nach oben

Insulin treatment improves islet function in type 2 diabetic Chinese hamsters
Kohnert, K.-D.; Hehmke, B.; Klöting, I.; Besch, W.; Ahren, B.
Exp. Clin. Endocrinol. Diabetes 109: 196-202 (2001)

Sequence variations in the NDUFA1 gene encoding a subunit of complex I of the respiratory chain
I. Wittig, P. Augstein, G.K. Brown, T. Fujii, A. Rötig, P. Rustin, A. Munnich, P. Seibel, D. Thorburn, B. Wissinger, K. Tamboom, A. Metspalu, E. Lamantea, M. Zeviani, M.S. Wehnert
J. Inherit. Dis. 24: 15-27 (2001)

2000 nach oben

Immunoadsorption of immunoglobulins alters intracytoplasmic type 1 and type 2 T cell cytokine production in patients with refractory autoimmune diseases
Hehmke, B.; Salzsieder, E.; Matic, G. B.; Winkler, R. E. ; Tiess, M.; Ramlow, W.
Therapeutic Apheresis 4: 296-302 (2000)

1999 nach oben

Relationship between the histopathology of the endocrine-exocrine pancreas parenchyma and beta cell function in the chinese hamster CHIG/Han subline
Kessler, J.; Hehmke, B.; Klöting, I.; Kohnert, K.-D.
Pancreas 19: 89-97 (1999)

Islet neuronal abnormalities associated with impaired insulin secretion in type 2 diabetes in the chinese hamster
Kohnert, K.-D.; Myrsen Axcrona, U.; Hehmke, B.; Klöting, I.; Sundler, F.; Ahren, B.
Regulatory Peptides 82: 71-79 (1999)

Complement-dependent antibody-mediated cytotoxicity to rat pancreatic exocrine cells in serum of diabetes-prone BB/OK rats and their congenic derivatives
Schröder, D.; Hehmke, B.; Klöting, I.; Schmidt, S.
Diabetes Res. 34: 45-57 (1999)

Glucagon-like peptide-1 has no insulin-like effects in insulin-dependent diabetic dogs maintained normoglycemic and normoinsulinemic
Freyse, E.-J., Knospe, S., Becher, T., El-Hag, O., Göke, B., Fischer, U.
Metabolism 48:134-137 (1999)

1998 nach oben

Estimation of urea production rate with [15N2]urea and [13C]urea to measure catabolic rates in diabetes mellitus
Freyse, E.-J., Knospe, S.
Isotopes Environ. Health Stud. 34: 107-118 (1998)

ß-cell destruction in islets in spontaneous and cyclophoshamide-accelerated diabetes of NOD mice
P. Augstein, A.G. Elefanty, J. Allison and L.C. Harrison, Apoptosis
Diabetologia 41: 1381-1388 (1998)

ß-cell apoptosis in an accelerated model of autoimmune diabetes
Augstein, P., Stephens, L.A., Allison, J., Elefanty, A.G., Ekberg, M., Kay, T.W.H., Harrison, L.C.
Mol Med 4: 495-501 (1998)

A peptide-binding motif for I-A(g7)
Harrison L.C., Honeyman M.C., Trembleau S., Gregori S., Gallazzi F., Augstein P., Brusic V., Hammer J., Adorini L.
the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. J Exp Med. 17, 185(6): 1013-21 (1998)

Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas
Harrison, M., Dunger A., Berg, S., Mabley, J., John, N., Green, M.H.L., Green, I.C.
FEBS Letters 435: 207-210 (1998)

Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes.
Augstein P, Elefanty AG, Allison J & Harrison LC 1998b
Diabetologia 41: 1381-1388.

A Beta-cell apoptosis in an accelerated model of autoimmune diabetes.
Augstein P, Stephens LA, Allison J, Elefanty AG, Ekberg M, Kay TW & Harrison LC 1998
Mol.Med. 4 495-501.

Mixed graphical models for simultaneous model identification and control applied to the glucose-insulin metabolism.
Bleckert G, Oppel UG & Salzsieder E 1998
Comput.Methods Programs Biomed. 56 141-155.

1997 nach oben

Immunological reactivity of diabetes-prone BB/OK rats to syngeneic antigens
Schröder, D.; Schmidt, S.; Klöting, I.; Honig, A.; Lucke, S.; Hehmke, B.; Schlosser, M.
Effect on ß-cell destruction and diabetes onset. In: Physiology and Pathophysiology of the Islets of Langerhans. Ed. by Soria, Plenum Press, New York, 345-353 (1997)

Blood glucose lowering and glucagonostatic effects of GLP-1 in insulin-deprived diabetic dogs
Freyse, E.-J., Becher, T., El-Hag, O., Knospe, S., Göke, B., Fischer, U.
Diabetes 46: 824-828 (1997)

Diabetes-induced alterations of protein metabolism in dependence on insulin substitution
Freyse, E.-J., Fischer, U.
Diabetes und Stoffwechsel 6(S1): 6 (1997)

Influence of route of insulin administration on protein metabolism in IDDM. Exp. Clin
Freyse, E.-J., Nair, K.S., Knospe, S., Heinke, P., Zschiesche, M., Fischer, U.
Endocrinol. Diabetes 105: A77 (1997)

Immunohistochemical differentiation of monoclonal GAD antibodies recognizing linear or conformational epitope regions
Augstein, P., Ziegler, B., Schlosser, M., Flassig, S., Strebelow, M., Ziegler, M.
Pancreas. 15(2): 139-46 (1997)

Sensitive monoclonal antibody-based sandwich ELISA for determination of the diabetes-associated autoantigen glutamic acid decarboxylase
Schlosser, M., Hahmann, J., Ziegler, B., Augstein, P., Ziegler, M.
GAD65. J Immunoassay 18(4): 289-307 (1997)

Circadian variations in blood pressure and heart rate in diabetes prone and resistant rat strains compared with spontaneously hypertensive rats
Berg, S., Dunger, A., Vogt, L., Schmidt, S.
Exp Clin Endocrinol Diabetes 105 (Suppl 2): 7-9 (1997)

Functional alterations in the rat kidney induced either by diabetes or high protein diet
Dunger, A., Berg, S., Klöting, I., Schmidt, S.
Exp Clin Endocrinol Diabetes 105 (Suppl 2): 48-50 (1997)

Diabetes and Hypertension in rodent models
Klöting, I., Berg, S., Kovacs, P., Voigt, B., Vogt, L., Schmidt, S.
Annals of the New York Academy of Sciences 827: 64-84 (1997)

WOK.1W Rats: A potential animal model of the insulin resistance syndrom
Kovacs, P., Voigt, B., Berg, S., Vogt, L., Klöting, I.
Annals of the New York Academy of Sciences 827: 94-99 (1997)

Congenic spontaneously diabetic hypertensive BB.SHR Rats
Voigt, B., Berg, S., Kovacs, P., Vogt, L., Klöting, I.
Transplantation Proceedings 29: 1677-1678 (1997)

A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice.
Harrison LC, Honeyman MC, Trembleau S, Gregori S, Gallazzi F, Augstein P, Brusic V, Hammer J & Adorini L 1997
J.Exp.Med. 185 1013-1021.

1996 nach oben

Antibody response to islet antigens in anti-CD4/prednisolone immune intervention of type 1 diabetes
Kohnert, K.-D.; Hehmke, B.; Keilacker, H.; Ziegler, M.; Emmrich, F.; Laube, F.; Michaelis, D.
Int. J. Clin. Lab. Res. 26, 55-59 (1996)

Differential expression of fructosyllysine-specific receptors on monocytes and macrophages and possible pathophysiological significance
Brandt, R.; Landmesser, C.; Vogt, L.; Hehmke, B.; Hanschke, R.; Kasbohm, J.; Hartmann, K.; Jäger, B.; Krantz, S.; Michaelis, D.
Diabetologia 39: 1140-1147 (1996)

Increased urea synthesis in insulin-dependent diabetic dogs maintained normoglycaemic
Freyse, E.-J., Rebrin, K., Scheider, T., Petrzika, M., Fischer, U.
Effect of portal insulin administration and of food protein contents. Diabetes 45: 667-674 (1996)

Comparison of the islet cell antibody pattern of monoclonal glutamic acid decarboxylase antibodies recognizing linear and conformational epitopes
Augstein, P., Schlosser, M., Ziegler, B., Hahmann, J., Mauch, L., Ziegler, M.
Acta Histochem. 98(2): 229-41 (1996)

Identification of Interleukin 1ß-induced apoptosis in rat islets by using in situ specific labeling of fragmented DNA
Dunger, A., Augstein, P., Schmidt, S.
Biochemica Information 99: 21-23 (1996)

Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA
Dunger, A., Augstein, P., Schmidt, S., Fischer, U.
J. Autoimmun. 9(3): 309-13 (1996)

Glutamate decarboxylase (GAD) is not detectable on the surface of rat islet cells examined by cytofluorometry and complement-dependent antibody-mediated cytotoxicity of monoclonal GAD antibodies
Ziegler, B., Augstein, P., Schröder, D., Mauch, L., Hahmann, J., Schlosser, M. and Ziegler, M.
Horm. Metab. Res. Jan; 28(1): 11-5 (1996)

Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome
Ziegler, B., Schlosser, M., Lühder, F., Strebelow, M., Augstein, P., Northemann, W., Powers, AC., Ziegler, M.
Acta Diabetol. 33(3): 225-31 (1996)

1995 nach oben

Impaired ß-cell function in the chinese hamster CHIG/Han subline
Kohnert, K.-D.; Hehmke, B.; Besch, W.; Keßler, J.; Klöting, I.
Exp. Clin. Endocrinol. 103, 66-70 (1995)

Aberrant activation of CD8+ T-cell and CD8+ T-cell subsets in patients with newly diagnosed IDDM
Hehmke, B.; Michaelis, D.; Gens, E.; Laube, F.; Kohnert, K.-D.
Diabetes 44, 1414-1419 (1995)

Metabolische Effekte von Glucagon-like peptide-1 (7-36) amid auf den Kohlenhydratstoffwechsel bei gesunden und bei insulinpflichtigem Diabetes mellitus (vorläufige Ergebnisse)
Becher, T, Elhag, O., Junghans, P., Knospe, S., Fischer, U., Freyse, E.-J.
3. Arbeitstagung Angewandte und Pathologische Physiologie, 28. September bis 1. Oktober 1994 in Königstein/Sächsische Schweiz/TU Dresden 1995, Hrsg. V. Sinz Dresden, H.-V. Ulmer Mainz, D. Wirth, Dresden

Biosensoren für Glukose-Anwendung in vivo
Abel, P., von Woedtke, T., Freyse, E.J., Schwock, A., Aßmus, K., Fischer, U.
Sensor 95 Kongressband ACS Wunstorf, pp. 941-944 (1995)

Impact of metabolic activity of beta cells on cytokine-induced damage and recovery of rat pancreatic islets
Dunger, A., Schröder, D., Augstein, P., Witstruck, T., Wachlin G., Vogt, L., Ziegler, B., Schmidt, S.
Acta Diabetol. 32(4): 217-24 (1995)

1994 nach oben

TKADIS: model-aided education in type I diabetes. Karlsburg Diabetes Management System.
Rutscher A, Salzsieder E & Fischer U 1994
Comput.Methods Programs Biomed. 41 205-215.

The detection of autoantibodies to pancreatic islet cells by immunoenzyme histochemistry
Kohnert, K.-D.; Rjasanowski, I.; Hehmke, B.; Hamann, J.; Keilacker, H.; Michaelis, D.
Diabetes Res. 25, 1-12 (1994)

Anti-CD4 monoclonal antibody immune intervention in patients with newly-diagnosed type I (insulin-dependent) diabetes mellitus
Hehmke, B.; Kuttler, B.; Laube, F.; Gens, E.; Michaelis, D.; Hahn, H.-J.; Emmrich, F.
Diab. Nutr. Metab. 7, 273-280 (1994)

Antibody-mediated islet cell cytotoxicity
Hehmke, B.; Schröder, D.; Kohnert, K.-D.
Frontiers of insulin secretion and pancreatic B-cell research. Ed. by P.R. Flatt and S. Lenzen, Smith-Gordon, London, 517-523 (1994)

Functional impairment and necrosis of pancreatic B-cells by synergistic effects of adjuvants and low dose streptozotocin
Kohnert, K.-D.; Hehmke, B.; Fält, K.; Odselius, R.; Klöting, I.; Falkmer, S.
Frontiers of insulin secretion and pancreatic B-cell research. Ed. by P.R. Flatt and S. Lenzen, Smith-Gordon, London, 525-534 (1994)

Demonstration of temperature dependence of Na+-K+ pump activity of human blood cells
Honig, A., Oppermann, H., Budweg, C., Goldbecher, H., Freyse, E.-J.
Am. J. Physiol. (Adv. Physiol. Educ. 11): 10-15 (1994)

Occurrence of islet cell reactive autoantibodies in diabetes-prone BB/OK rats is not associated with the onset of diabetes - a cross-sectional study of BB rats and their diabetes-resistant congenic strains
Schlosser, M., Ziegler, B., Augstein, P., Klöting, I. and Ziegler, M.
Diab. Res. 26: 67-77 (1994)

Monoclonal antibodies specific to the glutamic acid decarboxylase 65 kDa isoform derived from a non-obese diabetic (NOD) mouse
Ziegler, B., Augstein, P., Lühder, F., Northemann, W., Hamann, J., Schlosser, M., Klöting, I. and Ziegler, M.
Diabetes Res. 25(2): 47-64 (1994)

1993 nach oben

Effect of syngenic islet antigen administration on complement-dependent antibody-mediated cytotoxicity to islet cells and diabetes onset in diabetes-prone BB/OK rats
Schröder, D.; Schmidt, S.; Klöting, I.; Hehmke, B.
Autoimmunity 14, 283-289 (1993)

Modulation of the effect of humoral-mediated cytotoxicity on isolated rat pancreatic islets by glucose
Schröder, D.; Kohnert, K.-D.; Hehmke, B.; Besch, W.; Schmidt, S.
APMIS 101, 387-394 (1993)

Glucose analyses in subcutaneous tissues: references to the electrochemical approach
Fischer, U., Freyse, E.-J.
S. Alcock (ed.). Chemical Sensors for In Vivo Monitoring. Newsletter 11 (1993) 11-15

Pathobiochemie des Eiweißhaushaltes bei Diabetes mellitus
Freyse, E.-J.
Pathogenese des Diabetes mellitus und moderne Aspekte der Diagnostik. Hrsg.: B. Porstmann. - München: Urban und Vogel, 1993 (Fortschritte der Diagnostik), 49-54

Induction of islet cell surface and insulin antibodies in Balb/c mice by application of porcine insulin and Freund´s adjuvant is not associated with insulitis
Augstein, P., Kohnert, K.-D., Ziegler, B., Fürll, B., Heinke, P. and Ziegler, M.
Horm. Metab. Res. 25: 344-347 (1993)

Occurrence of Beta-cell specific antibodies in diabetes-prone BB/OK rats is not associated with the autoimmune progressive loss of Beta cells: A study with monoclonal antibodies
Augstein, P., Ziegler, B., Schlosser, M., Klöting, I., Ziegler, M.
Diab. Res. 23: 139-151 (1993)

Characterization of monoclonal islet cell reactive autoantibodies from the diabetic Biobreeding (BB/OK) Rat
Ziegler, B., Witt, S., Kohnert, K.-D., Schlosser, M., Augstein, P., Michaelis, D., Klöting, I. and Ziegler, M.
Acta diabetol., 30: 201-206 (1993)

A monoclonal antibody specific for proinsulin of different species, but not reactive with C-peptide or insulin
Ziegler, M., Hamann, J., Augstein, P., Woltanski, K.-P., Sturm, M., Kaufmann, K.
Chemistry of Peptides and Proteins: Proceeding of the seventh USSR-FRG Symp. on Chemistry of Peptides and Proteins, Dilizhan, USSR, Sept. 23-30, 1989 and the eighth FRG-USSR Symp., Aachen, FRG, Sept. 29 - Oct.3., 1991 (Eds D. Brandenburg, V. Ivanov, W. Voelter) Aachen: Verl. Mainz, 1993 (Deutsch. Wollforsch. Inst.: 112A + B)

Primary health care of diabetic patients in a specialized outpatient setting: a DIABCARE-based analysis.
Fischer U, Salzsieder E, Menzel R, Vogt L, Ropke H, Schmidt R & Heinke P 1993
Diabete Metab 19 188-194.

Humoral-mediated cytotoxicity to rat pancreatic exocrine cells in serum of diabetes-prone BB/OK rats--predictive value for diabetes onset.
Schroder D, Hehmke B, Kloting I & Schmidt S 1993
Diabetes Res. 23 105-113.

Diabetes prevalence from health insurance data: evaluation of estimates by comparison with a population-based diabetes register.
Von Ferber L, Salzsieder E, Hauner H, Thoelke H, Koster I, Jutzi E, Michaelis D & Fischer U 1993
Diabete Metab 19 89-95.

1992 nach oben

Monoclonal antibody-mediated cytotoxicity against rat beta cells detected in vitro does not cause beta-cell destruction in vivo
Ziegler, B.; Lucke, S.; Köhler, E.; Hehmke, B.; Schlosser, M.; Witt, S.; Ziegler, M.
Diabetologia 35, 608-613 (1992)

Immunological and ß-cell-specific characteristics of diabetes-prone BB/OK rats and their congenic derivatives - a comparative study
Schröder, D.; Klöting, I.; Hehmke, B.; Schmidt, S.
Diabetes Res. 20, 21-31 (1992)

Artificial connection between glucose sensing and insulin delivery
Fischer, U., Freyse, E.-J., Salzsieder, E., Rebrin, K.
implications of peritoneal administration. Artif.Organs 16 (1992) 151-162

Characterization of two porcine proinsulin reactive monoclonal antibodies by immunostaining of ß-cells in pancreatic sections of different species
Augstein, P., Braun, B., Ziegler, B., Woltanski, K.-P. and Ziegler, M.
Acta histochem. 93: 433-440 (1992)

1991 nach oben

Complement-dependent antibody-mediated cytotoxicity (C´AMC) to pancreatic islet cells in the spontaneously diabetic BB/OK rat: interference from cell-bound and soluble inhibitors
Hehmke, B.; Schröder, D.; Klöting, I.; Kohnert, K.-D.
J. Lab. Clin. Immunol. 35, 71-81 (1991)

Detection and time course of humoral mediated cytotoxicity to different cell types in diabetes-prone BB/OK rats
Schröder, D.; Hehmke, B.; Klöting, I.; Schmidt, S.
Diabetes Res. 17, 81-91 (1991)

Ein Leben lang Insulin spritzen? Neue Therapieformen auf dem Prüfstand- noch viele offene Frage
Freyse, E.J.
Diabetiker Magazin 1 (1991) 10-13

1990 nach oben

KADIS®-a computer-aided decision support system for improving the management of type-I diabetes.
Rutscher A, Salzsieder E, Thierbach U, Fischer U & Albrecht G 1990
Exp.Clin.Endocrinol. 95 137-147.

Computer-aided systems in the management of type I diabetes: the application of a model-based strategy.
Salzsieder E, Albrecht G, Fischer U, Rutscher A & Thierbach U 1990
Comput.Methods Programs Biomed. 32 215-224.

A model-based system for the individual prediction of metabolic responses to improve therapy in type I diabetes.
Salzsieder E, Fischer U, Stoewhas H, Thierbach U, Rutscher A, Menzel R & Albrecht G 1990
Horm.Metab Res.Suppl 2410-9 -9.

Autoimmune reactions in a patient with malignant insulinoma treated by multiple low dose streptozotocin
Schulz, B.; Hehmke, B.; Zander, E.; Ziegler, B.
Exp. Clin. Endocrinol. 95, 77-82 (1990)

Detection of antibodies to islet cells and splenic lymphocytes in diabetes-prone BB and adjuvant-streptozotocin treated Lewis rats by ELISA and immunoblot analysis
Kohnert, K.-D.; Besch, W.; Schröder, D.; Ziegler, B.; Hehmke, B.; Fält, K.; Ziegler, M.
Allerg. Immunol. 36, 321-331 (1990)

Development of cytotoxic islet cell antibodies in rats following damage of the pancreas by complete Freund´s adjuvant combined with a nondiabetogenic dose of streptozotocin
Kohnert, K.-D.; Ziegler, B.; Hehmke, B.; Fält, K.; Odselius, R.; Ziegler, M.
Int. J. Pancreatol. 6, 33-48 (1990)

Humoral-mediated anti-islet cytotoxicity in diabetes-prone BB/OK rats - effect on ß-cell function and autologous islets
Schröder, D.; Hehmke, B.; Klöting, I.; Besch, W.; Schmidt, S.
Exp. Clin. Endocrinol. 95, 22-30 (1990)

Beta cell destruction of pancreatic islets transplanted into diabetic BB/OK rats may be reflected by increased antibody-mediated anti-islet cytotoxicity
Schröder, D.; Wanka, H.; Hehmke, B.; Klöting, I.; Köhler, E.; Knospe, S.; Schmidt, S.
Diabetes Res. 15, 27-32 (1990)

Early appearance of complement-dependent antibody mediated cytotoxicity (C´AMC) to islet cells in serum of diabetes-prone BB/OK rats
Hehmke, B.; Schröder, D.; Klöting, I.
Diabetes Res. 13, 183-186 (1990)

Complement-dependent antibody-mediated cytotoxicity to islet cells in congenic BB/OK and congenic LEW rat strains: association with non-MHC genes
Hehmke, B.; Schröder, D.; Klöting, I.
Frontiers in diabetes research. Lessons from animal diabetes III. Ed. by E. Shafrir, Smith-Gordon, London, 38-40 (1990)

Umsatzraten im Glukosestoffwechsel bei experimentellem insulinabhängigem Diabetes mellitus unter dem Einfluß automatischer glukosekontrollierter Insulinverabfolgung
Freyse, E.J.
Greifswald, Univ., Med. Fak., Habilitation (1990)

Insulin therapy on the peritoneal route: effects on glucose control in experimental insulin dependent diabetes
Fischer, U., Fritze, K., Freyse, E.-J.
Exp. Clin. Endocrinol. 95 (1990) 11 - 21

Experimental validation of a glucose-insulin control model to simulate patterns in glucose turnover
Fischer, U., Salzsieder, E., Freyse, E.J., Albrecht, G.
Comp. Meth. Progr. Biomed. 32: 249-258 (1990)

Untersuchungen zur Bindung monoklonaler Antikörper an einer insulinproduzierenden Rattentumorzellinie (RIN) nach partieller Zellsynchronisierung
Ziegler, B., Schlosser, M., Witt, S., Bürgelt, P. und Ziegler, M.
Acta Histochem., Suppl. 36: 443-449 (1990)

Complement-dependent antibody-mediated cytotoxicity in the spontaneously diabetic BB/OK rat: association with beta cell volume density.
Hehmke B, Lucke S, Schroder D, Kloting I & Kohnert KD 1990
Eur.J.Immunol. 20 1091-1096.

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